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There was neither adrenal insufficiency nor hypocalcemia.

Hashimoto's thyroiditis was also diagnosed because she had a diffuse goiter and a mild hypothyroidism (TSH 8.20 μU/mL, and FT4 0.80 ng/mL) with positive autoantibodies for thyroid peroxidase and thyroglobulin. Accordingly, type 1 diabetes was diagnosed. Glutamic acid decarboxylase (GAD) and IA-2 antibodies were positive, and the serum C peptide level was markedly decreased to 0.2 ng/mL. Laboratory tests revealed severe hyperglycemia (plasma glucose 543 mg/dL and HbA1c 10.7%) with ketonuria (3+). A previously healthy 65-year-old Japanese woman was referred to our university hospital with a 2-month history of general fatigue and hyperglycemia. We describe a very rare case of concurrent variant type 3 autoimmune polyglandular syndrome (APS) and pulmonary arterial hypertension (PAH).

Iijima, Toshie Niitani, Takafumi Tanaka, Seiichi Yanagi, Kazunori Jojima, Teruo Suzuki, Kunihiro Usui, Isao Aso, Yoshimasa The present case is the first to reveal a clear match of laterality between clinical parkinsonism, MRI-based substantia nigra lesions, and impaired DAT in presynaptic dopaminergic neurons in JE.Ĭoncurrent variant type 3 autoimmune polyglandular syndrome and pulmonary arterial hypertension in a Japanese woman. Dopamine transporter (DAT) imaging using 123 I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane ( 123 I-FP-CIT) revealed a corresponding left-dominant decrease. A 67-year-old woman with JE showed right-dominant clinical parkinsonism and left-dominant substantia nigra lesions after magnetic resonance imaging (MRI). Japanese encephalitis (JE) survivors often present with nigrostriatal aftereffects with parkinsonian features. Tadokoro, Koh Ohta, Yasuyuki Sato, Kota Maeki, Takahiro Sasaki, Ryo Takahashi, Yoshiaki Shang, Jingwei Takemoto, Mami Hishikawa, Nozomi Yamashita, Toru Lim, Chang Kweng Tajima, Shigeru Abe, Koji
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